Name | 2-Methoxyethyl acetoacetate |
Synonyms | ACMOE Nitrendipine Impurity R Methoxyethylacetoacetate Methoxyethyl acetoacetat 2-Methoxyethyl acetoacetate 2-METHOXYETHYL ACETOACETATE 2-Methoxyethyl 3-oxobutanoate ACETOACETIC ACID 2-METHOXYETHYL ESTER ACETOACETIC ACID 2-(METACRYLOXY)ETHYL ESTER butanoic acid, 3-oxo-, 2-methoxyethyl ester 2-METHOXYETHYL ACETOACETATE, WACKER QUAL ITY |
CAS | 22502-03-0 |
EINECS | 245-043-8 |
InChI | InChI=1/C7H12O4/c1-6(8)5-7(9)11-4-3-10-2/h3-5H2,1-2H3 |
Molecular Formula | C7H12O4 |
Molar Mass | 160.17 |
Density | 1.09g/mLat 25°C(lit.) |
Boling Point | 120°C20mm Hg(lit.) |
Flash Point | 218°F |
Water Solubility | 100g/L at 20℃ |
Vapor Presure | 0.0721mmHg at 25°C |
Appearance | liquid |
Color | clear |
BRN | 2079850 |
pKa | 10.37±0.46(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | n20/D 1.434(lit.) |
MDL | MFCD00009648 |
Use | Used as an organic intermediate |
Risk Codes | R60 - May impair fertility R61 - May cause harm to the unborn child R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
HS Code | 29183000 |
Overview | Methoxyethyl acetoacetate can be used to prepare cilnidipine intermediate 2-(3-nitrobenzylidene) methoxyethyl acetoacetate. Cilnidipine was developed by Fuji Corporation of Japan and was first listed in Japan in December 1995. The chemical name of cilnidipine is: racemic 2, 6-dimethyl-4 (3-nitrobenzene) -1, 4-dihydropyridine-3, 5-dicarboxylic acid -2-methoxyethyl (E)-3-phenyl-2-propenyl diester. Cilnidipine is a lipophilic dihydropyridine calcium antagonist, which can bind to the dihydropyridine site of the L-type calcium channel on the vascular smooth muscle cell membrane, and inhibit the transmembrane flow of Ca2 through the L-type calcium channel, thereby Relax and expand vascular smooth muscle, play a role in lowering blood pressure. The specific steps are as follows: |
Uses | Methoxyethyl acetoacetate is used as an organic intermediate to make nimodipine. |